Pesquisa | BVS Violência e Saúde

1.

ß-Arrestin-Biased Allosteric Modulator of NTSR1 Selectively Attenuates Addictive Behaviors.

Slosky, Lauren M; Bai, Yushi; Toth, Krisztian; Ray, Caroline; Rochelle, Lauren K; Badea, Alexandra; Chandrasekhar, Rahul; Pogorelov, Vladimir M; Abraham, Dennis M; Atluri, Namratha; Peddibhotla, Satyamaheshwar; Hedrick, Michael P; Hershberger, Paul; Maloney, Patrick; Yuan, Hong; Li, Zibo; Wetsel, William C; Pinkerton, Anthony B; Barak, Lawrence S; Caron, Marc G.

Cell ; 181(6): 1364-1379.e14, 2020 06 11.

Artigo em Inglês | MEDLINE | ID: mdl-32470395

2.

Brain-wide Electrical Spatiotemporal Dynamics Encode Depression Vulnerability.

Hultman, Rainbo; Ulrich, Kyle; Sachs, Benjamin D; Blount, Cameron; Carlson, David E; Ndubuizu, Nkemdilim; Bagot, Rosemary C; Parise, Eric M; Vu, Mai-Anh T; Gallagher, Neil M; Wang, Joyce; Silva, Alcino J; Deisseroth, Karl; Mague, Stephen D; Caron, Marc G; Nestler, Eric J; Carin, Lawrence; Dzirasa, Kafui.

Cell ; 173(1): 166-180.e14, 2018 03 22.

Artigo em Inglês | MEDLINE | ID: mdl-29502969

3.

Neurotensin Receptor Allosterism Revealed in Complex with a Biased Allosteric Modulator.

Krumm, Brian E; DiBerto, Jeffrey F; Olsen, Reid H J; Kang, Hye Jin; Slocum, Samuel T; Zhang, Shicheng; Strachan, Ryan T; Huang, Xi-Ping; Slosky, Lauren M; Pinkerton, Anthony B; Barak, Lawrence S; Caron, Marc G; Kenakin, Terry; Fay, Jonathan F; Roth, Bryan L.

Biochemistry ; 62(7): 1233-1248, 2023 04 04.

Artigo em Inglês | MEDLINE | ID: mdl-36917754

4.

Prenatal heroin exposure alters brain morphology and connectivity in adolescent mice.

Hornburg, Kathryn J; Slosky, Lauren M; Cofer, Gary; Cook, James; Qi, Yi; Porkka, Fiona; Clark, Nicholas B; Pires, Andrea; Petrella, Jeffrey R; White, Leonard E; Wetsel, William C; Barak, Lawrence; Caron, Marc G; Johnson, G Allan.

NMR Biomed ; 36(2): e4842, 2023 02.

Artigo em Inglês | MEDLINE | ID: mdl-36259728

5.

Effects of Serotonin and Slow-Release 5-Hydroxytryptophan on Gastrointestinal Motility in a Mouse Model of Depression.

Israelyan, Narek; Del Colle, Andrew; Li, Zhishan; Park, Yeji; Xing, Albert; Jacobsen, Jacob P R; Luna, Ruth Ann; Jensen, Dane D; Madra, Moneek; Saurman, Virginia; Rahim, Ray; Latorre, Rocco; Law, Kimberly; Carson, William; Bunnett, Nigel W; Caron, Marc G; Margolis, Kara G.

Gastroenterology ; 157(2): 507-521.e4, 2019 08.

Artigo em Inglês | MEDLINE | ID: mdl-31071306

6.

Loss of ß-arrestin2 in D2 cells alters neuronal excitability in the nucleus accumbens and behavioral responses to psychostimulants and opioids.

Porter-Stransky, Kirsten A; Petko, Alyssa K; Karne, Saumya L; Liles, L Cameron; Urs, Nikhil M; Caron, Marc G; Paladini, Carlos A; Weinshenker, David.

Addict Biol ; 25(6): e12823, 2020 11.

Artigo em Inglês | MEDLINE | ID: mdl-31441201

7.

The dopamine D2 receptor can directly recruit and activate GRK2 without G protein activation.

Pack, Thomas F; Orlen, Margo I; Ray, Caroline; Peterson, Sean M; Caron, Marc G.

J Biol Chem ; 293(16): 6161-6171, 2018 04 20.

Artigo em Inglês | MEDLINE | ID: mdl-29487132

8.

Distinct cortical and striatal actions of a ß-arrestin-biased dopamine D2 receptor ligand reveal unique antipsychotic-like properties.

Urs, Nikhil M; Gee, Steven M; Pack, Thomas F; McCorvy, John D; Evron, Tama; Snyder, Joshua C; Yang, Xiaobao; Rodriguiz, Ramona M; Borrelli, Emiliana; Wetsel, William C; Jin, Jian; Roth, Bryan L; O'Donnell, Patricio; Caron, Marc G.

Proc Natl Acad Sci U S A ; 113(50): E8178-E8186, 2016 12 13.

Artigo em Inglês | MEDLINE | ID: mdl-27911814

9.

Inhibiting clathrin-mediated endocytosis of the leucine-rich G protein-coupled receptor-5 diminishes cell fitness.

Snyder, Joshua C; Rochelle, Lauren K; Ray, Caroline; Pack, Thomas F; Bock, Cheryl B; Lubkov, Veronica; Lyerly, H Kim; Waggoner, Alan S; Barak, Larry S; Caron, Marc G.

J Biol Chem ; 292(17): 7208-7222, 2017 04 28.

Artigo em Inglês | MEDLINE | ID: mdl-28275053

10.

Mechanisms of neuroprotection against ischemic insult by stress-inducible phosphoprotein-1/prion protein complex.

Beraldo, Flavio H; Ostapchenko, Valeriy G; Xu, Jason Z; Di Guglielmo, Gianni M; Fan, Jue; Nicholls, Peter J; Caron, Marc G; Prado, Vania F; Prado, Marco A M.

J Neurochem ; 145(1): 68-79, 2018 04.

Artigo em Inglês | MEDLINE | ID: mdl-29265373

11.

Protamine is an antagonist of apelin receptor, and its activity is reversed by heparin.

Le Gonidec, Sophie; Chaves-Almagro, Carline; Bai, Yushi; Kang, Hye Jin; Smith, Allyson; Wanecq, Estelle; Huang, Xi-Ping; Prats, Hervé; Knibiehler, Bernard; Roth, Bryan L; Barak, Larry S; Caron, Marc G; Valet, Philippe; Audigier, Yves; Masri, Bernard.

FASEB J ; 31(6): 2507-2519, 2017 06.

Artigo em Inglês | MEDLINE | ID: mdl-28242772

12.

Ghrelin receptor antagonism of hyperlocomotion in cocaine-sensitized mice requires ßarrestin-2.

Toth, Krisztian; Slosky, Lauren M; Pack, Thomas F; Urs, Nikhil M; Boone, Peter; Mao, Lan; Abraham, Dennis; Caron, Marc G; Barak, Lawrence S.

Synapse ; 72(1)2018 01.

Artigo em Inglês | MEDLINE | ID: mdl-28941296

13.

Brain 5-HT deficiency increases stress vulnerability and impairs antidepressant responses following psychosocial stress.

Sachs, Benjamin D; Ni, Jason R; Caron, Marc G.

Proc Natl Acad Sci U S A ; 112(8): 2557-62, 2015 Feb 24.

Artigo em Inglês | MEDLINE | ID: mdl-25675490

14.

Targeting ß-arrestin2 in the treatment of L-DOPA-induced dyskinesia in Parkinson's disease.

Urs, Nikhil M; Bido, Simone; Peterson, Sean M; Daigle, Tanya L; Bass, Caroline E; Gainetdinov, Raul R; Bezard, Erwan; Caron, Marc G.

Proc Natl Acad Sci U S A ; 112(19): E2517-26, 2015 May 12.

Artigo em Inglês | MEDLINE | ID: mdl-25918399

15.

Elucidation of G-protein and ß-arrestin functional selectivity at the dopamine D2 receptor.

Peterson, Sean M; Pack, Thomas F; Wilkins, Angela D; Urs, Nikhil M; Urban, Daniel J; Bass, Caroline E; Lichtarge, Olivier; Caron, Marc G.

Proc Natl Acad Sci U S A ; 112(22): 7097-102, 2015 Jun 02.

Artigo em Inglês | MEDLINE | ID: mdl-25964346

16.

Lgr4 and Lgr5 drive the formation of long actin-rich cytoneme-like membrane protrusions.

Snyder, Joshua C; Rochelle, Lauren K; Marion, Sébastien; Lyerly, H Kim; Barak, Larry S; Caron, Marc G.

J Cell Sci ; 128(6): 1230-40, 2015 Mar 15.

Artigo em Inglês | MEDLINE | ID: mdl-25653388

17.

Design, synthesis and biological evaluation of GPR55 agonists.

Fakhouri, Lara; Cook, Christopher D; Al-Huniti, Mohammed H; Console-Bram, Linda M; Hurst, Dow P; Spano, Michael B S; Nasrallah, Daniel J; Caron, Marc G; Barak, Larry S; Reggio, Patricia H; Abood, Mary E; Croatt, Mitchell P.

Bioorg Med Chem ; 25(16): 4355-4367, 2017 08 15.

Artigo em Inglês | MEDLINE | ID: mdl-28673732

18.

Structural biology: Antidepressants at work.

Caron, Marc G; Gether, Ulrik.

Nature ; 532(7599): 320-1, 2016 Apr 21.

Artigo em Inglês | MEDLINE | ID: mdl-27049942

19.

Design, synthesis, and analysis of antagonists of GPR55: Piperidine-substituted 1,3,4-oxadiazol-2-ones.

Meza-Aviña, Maria Elena; Lingerfelt, Mary A; Console-Bram, Linda M; Gamage, Thomas F; Sharir, Haleli; Gettys, Kristen E; Hurst, Dow P; Kotsikorou, Evangelia; Shore, Derek M; Caron, Marc G; Rao, Narasinga; Barak, Larry S; Abood, Mary E; Reggio, Patricia H; Croatt, Mitchell P.

Bioorg Med Chem Lett ; 26(7): 1827-1830, 2016 Apr 01.

Artigo em Inglês | MEDLINE | ID: mdl-26916440

20.

A rapid and affordable screening platform for membrane protein trafficking.

Snyder, Joshua C; Pack, Thomas F; Rochelle, Lauren K; Chakraborty, Subhasish K; Zhang, Ming; Eaton, Andrew W; Bai, Yushi; Ernst, Lauren A; Barak, Larry S; Waggoner, Alan S; Caron, Marc G.

BMC Biol ; 13: 107, 2015 Dec 17.

Artigo em Inglês | MEDLINE | ID: mdl-26678094

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